Until now studies reported inconclusive results in regards to the effectiveness of the exclusive use of robot-assisted training and clinical indications in stroke patients. To evaluate the feasibility of robot-assisted end-effector-based gait training (G-EO System) only in chronic stroke subjects in terms of gait performance and related parameters. Five rehabilitation centres participated and one hundred chronic post-stroke patients were recruited. Patients underwent robot-assisted end-effector-based gait training as the only treatment. 6 Minute Walking Test, 10 Meter Walk Test, Timed Up and Go Test, Modified Ashworth Scale, Motricity Index, Functional Ambulation Classification (FAC) and Walking Handicap Scale were used to measure the clinical outcome. Patients were divided into two groups: Those assessed as FAC < 3 (Group 1) and as FAC \u2265 3 (Group 2). Statistically significant changes were observed in each clinical outcome measure. Significant changes were observed in Group 1 and in Group 2. Significant percentages of patients achieved MCID in 6MWT in Group 2 and TUG in Group 1. Chronic stroke patients exposed to gait training with G-EO System only, showed significant improvements in global motor performances, gait endurance, balance and coordination, lower limbs strength and even spasticity reduction.<\/p>\n